Opening Day Cleveland Guardians 2025. The guardians home opener, the 32nd at progressive field, is slated for april 8 against the chicago white sox. On april 8, the cleveland guardians will host the chicago white sox in what will mark the team's 2025 home opener at progressive field.

While the cubs and dodgers will kick things off earlier, mlb’s traditional opening day presented by chevrolet will feature all 30 teams in action. On april 8, the cleveland guardians will host the chicago white sox in what will mark the team’s 2025 home opener at progressive field.